An exploratory study on wet syndrome

Phase 1

Recruiting

• Conditions: eczema

• Registration Number: ITMCTR2100004602
• Lead Sponsor: Guangdong Provincial Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Eczema patient group

(1)Patients with eczema diagnosed by western medicine;
(2)The functions of the heart, liver, lung, kidney and other important organs are basically normal;
(3)Participate in this study voluntarily and sign the informed consent form (patients under 18 years old need to be signed by a guardian at the same time).
2. Patients with eczema wet syndrome group

(1)Patients with eczema in western medicine and syndrome differentiation in Traditional Chinese medicine meet the criteria for determining wet syndrome;
(2)The functions of the heart, liver, lung, kidney and other important organs are basically normal;
(3)Participate in this study voluntarily and sign the informed consent form (patients under 18 years old need to be signed by a guardian at the same time).
3. Healthy control group

(1)Routine physical examination and stool routine were normal;
(2)Regular defecation, no history of diarrhea or other gastrointestinal diseases in the past 1 month;
(3)Subjects sign written informed consent to participate in this study (patients under the age of 18 shall be signed by their parents or guardians).

Exclusion Criteria

1. Eczema patient group

(1) Metabolic diseases (such as hypertension, diabetes, etc.), cardiovascular and cerebrovascular diseases, Parkinson's disease, infection, malignant tumors, liver/kidney diseases;
(2) Gastrointestinal and hepatobiliary inflammatory diseases, gastrointestinal diseases, tuberculosis, parasites, etc.;
(3) Special population: pregnant/lactating women, mental patients, etc.;
(4) Combined with other skin diseases that need treatment, such as psoriasis, alopecia areata, scabies, etc.;
(5) Patients who had received immunosuppressants, microecological preparations, glucocorticoids or antibiotics within 12 weeks.
(6) Patients with a history of smoking in half a year.
2. Patients with eczema wet syndrome group

(1) Metabolic diseases (such as hypertension, diabetes, etc.), cardiovascular and cerebrovascular diseases, Parkinson's disease, infection, malignant tumors, liver/kidney diseases;
(2) Gastrointestinal and hepatobiliary inflammatory diseases, gastrointestinal diseases, tuberculosis, parasites, etc.;
(3) Special population: pregnant/lactating women, mental patients, etc.;
(4) Combined with other skin diseases that need treatment, such as psoriasis, alopecia areata, scabies, etc.;
(5) Patients who had received immunosuppressants, microecological preparations, glucocorticoids or antibiotics within 12 weeks.
(6) Patients with a history of smoking in half a year.
3. Healthy control group

(1) An individual or his or her immediate family member has a history of allergic diseases, such as asthma, allergic rhinitis, allergic conjunctivitis, urticaria, eczema, etc.;
(2) Have taken antibiotics and microecological preparations in the past 1 month;
(3) Pregnant or lactating women.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EASI;

Secondary Outcome Measures

Name	Time	Method
Patient eczema Self-monitoring Scale;Visual Analog Scale;Skin Quality of Life Index questionnaire;(Wet syndrome - eczema) Information Collection table of TCM symptoms;Visual Analog Scale;Chinese Medicine Wet syndrome Evaluation Scale;