Intrauterine Growth Restriction Has an Impact on Amplitude-integrated EEG in Preterm Infants
试验速览
- 阶段
- 不适用
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- aEEG score (including background pattern, occurrence of sleep-wake-cycling and presence of seizure activity)
研究概览
简要总结
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies. Throughout this analysis, the influence of IUGR on the postnatal amplitude-integrated EEG (aEEG) in preterm infants below 30 weeks of gestation was assessed. The second concern was the correlation between the pattern of the aEEG in the first two weeks with neurodevelopmental outcome, comparing infants with and without IUGR.
Methods: Routinely assessed aEEG data of preterm infants with IUGR born below 30 weeks of gestation in the years 2005 until 2007 were analysed retrospectively according to the aEEG score (combining occurrence of sleep-wake-cycles, background activity and suspected seizure activity). Neurodevelopmental outcome was evaluated at 24 months using the Bayley Scales of Infant Development and standardized neurologic examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 23 Weeks 至 30 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •preterm infants below 30 weeks of gestation
排除标准
- •congenital anomalies
- •severe asphyxia
结局指标
主要结局
aEEG score (including background pattern, occurrence of sleep-wake-cycling and presence of seizure activity)
时间窗: first 14 days of life
composite score background activity (BA), occurrence of sleep-wake-cycling (SWC) and presence of seizure activity (SA) meaning score 1= normal (normal BA, SWC yes, SA no) and score 2 and 3 = abnormal (2=abnormality in 1 category (BA, SWC or SA) and score 3= abnormality in 2 or 3 categories
次要结局
- Neurodevelopmental outcome(24 months)
研究者
Katrin Klebermass-Schrehof
MD
Medical University of Vienna