Intra Uterine Growth Retardation;Causes and Relationship
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80,000
- 试验地点
- 1
- 主要终点
- The frequency of newborns with an affected perinatal outcome (low Apgar score and or affected acid-base status at labor)
研究概览
简要总结
Intrauterine growth restriction (IUGR) is a pregnancy complication in about 3-5% of all pregnancies in Sweden. IUGR fetuses are at high risk of morbidity and death. The method used in Sweden to detect IUGR is repeated measurements of pregnant women's symphysis-fundus measure (SF measure).
Weight estimation with ultrasound is performed only on indication; stagnant or deplaning SF dimensions or in the event of complications. Only high-risk pregnancies have repeated growth checks during pregnancy from the beginning.
There are potential benefits to detecting IUGR fetuses during pregnancy. Still, the effect is questioned. A meta-analysis of randomized studies could not benefit from a routine ultrasound in the third trimester.
The scientific purpose of this work is to evaluate the benefits of early detection and care of SGA (small for gestational age)/IUGR (growth-inhibited) fetuses and, if possible, to increase knowledge about this patient group. The hope is that this will lead to a better opportunity to personalize both preventive care and treatment of these women and children.
详细描述
Design: Register-based cohort study. Population: All pregnancies in Stockholm from 2014 to 2017 A Composite outcome for the study is constructed and consists of at least one of the following outcomes
- HIE (hypoxic-ischemic encephalopathy)2-3 (neonatal convulsions in the fetus after childbirth),
- Intracranial hemorrhage,
- Apgar score < 4 at 5 minutes,
- Arterial umbilical cord pH (potential of hydrogen) < 7.10,
- Intrauterine fetal death, 6)intrapartal death.
Inclusion: All pregnancies in Stockholm with a fetus, born between 2014 and 2017 and without chromosomal abnormalities or other structural abnormalities, will be included in the project.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All pregnancies in Stockholm with a fetus, born between 2014 and 2017 and without chromosomal abnormalities or other serious structural abnormalities, will be included in the project.
排除标准
- •Pregnancies with known chromosomal abnormalities or other serious structural abnormalities
结局指标
主要结局
The frequency of newborns with an affected perinatal outcome (low Apgar score and or affected acid-base status at labor)
时间窗: 2014-2017
Will the perinatal outcome at delivery( be measured as a low Apgar score at 5 minutes or an affected acid-base status in cord blood) be improved if IUGR(intrauterine growth restriction) is identified before labor
次要结局
- The frequency of newborns with an affected perinatal outcome (low Apgar score and or affected acid-base status at labor)(2)(January 1th 2014- december 31th 2017)
研究者
Eva Wiberg-Itzel
Associate professor
Karolinska Institutet