Effect of treatment in Lowering of ammonia level in the blood in the liver disease
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Acute on Chronic Liver Failure Patients With Hepatic EncephalopathyHealth Condition 2: K746- Other and unspecified cirrhosis ofliver
- Registration Number
- CTRI/2018/02/011999
- Lead Sponsor
- Institute of liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 73
Inclusion Criteria
1)Age 18 years and above
2)Patients with ACLF with grade III/IV HE
Exclusion Criteria
1)Patients with prior decompensation
2)Grade I,II HE
3)Chronic HE
4)CV stroke
5)Patients with ammonia level less than 70 mcg/dL
6)Patients with Septic shock
7)Pregnant lady
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of ammonia level to less than 70 mcg/dL within 72 hours of the ammonia reduction treatment.Timepoint: Reduction of ammonia level to less than 70 mcg/dL within 72 hours of the ammonia reduction treatment.
- Secondary Outcome Measures
Name Time Method Duration of hepatic encephalopathy post-inclusion.Timepoint: 10 days;Duration of ICU stay.Timepoint: 10 days;Improvement in hepatic encephalopathy from grade III-IV to II-I at any time within 72 hours of treatment.Timepoint: 3 days;Liver disease related and overall mortality.Timepoint: 10 days;Reduction of ammonia level to at least 50% of the baseline value within 72 hours.Timepoint: 3 days