Preoperative Acetaminophen and Carbohydrate Loading

Phase 3

Completed

Brief Summary: The study's goal is to assess impact of preoperative acetaminophen and oral carbohydrate drinks on pain and functional status experienced by patients undergoing Mohs micrographic surgery for non-melanoma skin cancers. Patients are randomly assigned to receive standard of care or preoperative acetaminophen 1000 mg and Gatorade sports drinks 2 packets before surgery. Patients are then asked to rate their level of pain, anxiety, thirst, hunger, fatigue on a scale of 0-100 on day of surgery before surgery has started, after clearance of skin cancer, and at the end of the visit. Patients are contacted by phone 48 hours after their surgery to assess their maximum level of post-operative pain (rated from 0-100), usage of over the counter or prescribed pain medications, and presence of complications e.g. bleeding, infection, dehiscence. Differences in perioperative functional status and pain medication usage are compared between patients in control and intervention groups.

Recruitment & Eligibility

Inclusion Criteria

Adult patients undergoing Mohs micrographic surgery for non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma)

Exclusion Criteria

history of liver transplant, hepatitis, or cirrhosis, those required to be NPO for subsequent closure by other surgical specialties, or those with known allergy to acetaminophen

Arm && Interventions

Group	Intervention	Description
Intervention	Acetaminophen	The intervention group, in addition to usual care, will receive Acetaminophen 1000mg and commercially available carbohydrate drink (two pouches of Gatorade Prime Sports Fuel drink containing 50gm carbohydrate in approximately 250ml fluid total) at the beginning of the surgery.

Primary Outcome Measures

Name	Time	Method
Maximum Pain Score	Day of surgery	Rated on a pain scale of 0-100. Higher score means worse outcome; lower score means better outcome.

Secondary Outcome Measures

Name	Time	Method
Anxiety	Day of surgery	Rated on n anxiety scale of 0-100. Higher score means worse outcome; lower score means better outcome.
Thirst	Day of surgery	Rated on a thirst scale of 0-100. Higher score means worse outcome; lower score means better outcome.
Number of Participants Using Post-operative Analgesic	48 hours after surgery	Number of participants using over the counter and prescribed non-opioid and opioid pain medications
Hunger	Day of surgery	Rated on a hunger scale of 0-100. Higher score means worse outcome; lower score means better outcome.
Fatigue	Day of surgery	Rated on a fatigue scale of 0-100. Higher score means worse outcome; lower score means better outcome.
Maximum Post-op Pain Score	48 hours after surgery	Rated on a maximum post-op pain scale of 0-100. Higher score means worse outcome; lower score means better outcome.