Effects of Blood Flow Restriction Training on Exercises in Healthy Individuals.

Not Applicable

Completed

• Conditions: Health, Subjective
• Interventions: Procedure: Aerobic exercises; Procedure: Resisted exercises

• Registration Number: NCT06254586
• Lead Sponsor: Prince Sattam Bin Abdulaziz University

Brief Summary

Partial restriction of blood flow to working muscles during exercise is proven to increase muscle mass and strength even with low-intensity of exercise. Blood Flow Restriction Training (BFRT) is also beneficial to improve the maximum rate of oxygen consumption (VO2max), bone health, and vascular health. Recent studies focus on its effects beyond the musculoskeletal system. Post-exercise hypotension is a known acute physiological response that happens after intense exercise. Early studies demonstrated BFRT might amplify the acute hypotensive effects with low intensity of exercise. However, it's not clear what type of exercise would help to lower blood pressure when it is combined with BFRT.

Detailed Description

Partial restriction of blood flow to working muscles during exercise is proven to increase muscle mass and strength even with low-intensity of exercise. Blood Flow Restriction Training (BFRT) is also beneficial to improve the maximum rate of oxygen consumption (VO2max), bone health, and vascular health. Recent studies focus on its effects beyond the musculoskeletal system. Post-exercise hypotension is a known acute physiological response that happens after intense exercise. Early studies demonstrated BFRT might amplify the acute hypotensive effects with low intensity of exercise. However, it's not clear what type of exercise would help to lower blood pressure when it is combined with BFRT. Considering BFRT, it's safe to implement among hypertensive individuals as per recent studies. It's still unclear what type of exercise would benefit maximum in reducing blood pressure while using it along BFR. The study aims to determine whether BFRT can influence BP, MAP, HR, and muscle girth differently while doing resisted exercises and aerobic exercise. Understanding the effects of BFRT on these parameters can provide valuable insights for optimizing exercise protocols and improving overall health outcomes. In general, this study can also add to the increasing amount of studies about the possible advantages and drawbacks of BFRT, and provide guidance on how to design exercise programs for people with borderline hypertension or in those with early phase of hypertension.

Study Timeline

• Study Start: 2022-04-01
• Primary Completion: 2023-10-30
• Study Completion: 2023-10-30
• Status Verified: 2024-02
• Study First Submitted: 2024-02-03
• Study First Submitted QC: 2024-02-03
• Last Update Submitted: 2024-02-03
• Study First Posted: 2024-02-12
• Last Update Posted: 2024-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 480

Inclusion Criteria

• Healthy adults of both gender, between the ages of 18 and 35 years
• Adults who are not participating in any regular exercise/fitness programmes for the last three months

Exclusion Criteria

• Adults with previous history of cardiovascular diseases, or with pathological changes in ECG
• Adults with concomitant illness such as diabetes, hypertension, or kidney diseases
• Chronic smokers or alcoholics
• Those with recent history of injury to lower limbs or with implants in lower limbs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aerobic exercise	Aerobic exercises	This group received a single session of low-intensity cycling for 20 minutes.
Resisted exercises	Resisted exercises	This group received four sets of 15 repetitions of knee extension, hamstring curls, and standing calf raises (20-40% 1RM) with a 30 sec to 1 minute rest period between sets.

Primary Outcome Measures

Name	Time	Method
Blood pressure	After 30 minutes	BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.
Mean arterial pressure	After 30 minutes	Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.
Heart rate	After 30 minutes	The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.
Muscle girth	After 30 minutes	For biceps measurement, the individual should flex their arm at a 90-degree angle.; Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight.; Record the measurement in inches or centimeters.

Trial Locations

Locations (1)

Gopal Nambi; 🇸🇦 Al Kharj, Riyadh, Saudi Arabia