Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors

Not Applicable

• Conditions: Necrotic Pulp
• Interventions: Procedure: revitalization by concentrated growth factor

• Registration Number: NCT05522270
• Lead Sponsor: Ahmad Elheeny

Brief Summary

Regenerative endodontic procedures (REPs) are the most recent proposal to manage immature permanent teeth with necrotic pulps. So in this study, the investigator will evaluate the clinical and radiographical revitalization success in necrotic young permanent anterior teeth of participants by using Concentrated Growth Factor versus Platelet-Rich Fibrin

Detailed Description

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Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-22
• Study First Submitted QC: 2022-08-28
• Last Update Submitted: 2022-08-28
• Study First Posted: 2022-08-31
• Last Update Posted: 2022-08-31
• Study Start: 2022-09-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Healthy patients with immature permanent incisors
• Presence of clinical signs and symptoms of necrosis or chronic apical periodontitis. The chronic apical periodontitis signs and symptoms include little discomfort with intermittent episodes of pus discharge through the sinus tract.

Exclusion Criteria

1. Abnormal tooth mobility.

• Positive history of allergic reaction, systemic diseases, severe emotional or behavioral problems.
• Unrestorable teeth
• Abnormal tooth mobility
• Children with systemic, severe behavioral, or emotional problems

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
revitalization by platelet rich fibrin	revitalization by concentrated growth factor	platelet concentrate
revitalization by concentrated growth factor	revitalization by concentrated growth factor	modified platelet concentrate

Primary Outcome Measures

Name	Time	Method
Radiographic success using Periapical index (PAI)	one year	Criteria of PAI scores: score "1" normal periapical structure score "2" small changes in bone structures score "3" changes in bone structure with some mineral loss score "4" periodontitis with well-defined radiolucent area score "5" severe periodontitis with exacerbating features
Clinical success rate	one year	Regaining tooth vitality with electric pulp testing Clinical examination includes pain absence, normal tooth mobility, and no sensitivity to percussion