Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients, Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 12
- 主要终点
- Change in Periodontal pocket depth measured in mm
研究概览
简要总结
Platelet rich fibrin (PRF) has been widely used in regenerative dentistry since it provides plenty amount of growth factors that enhance wound healing and tissue regeneration. Platelet derived growth factor-BB (PDGF-BB) is a growth factor with essential functions such as regulation of cell migration, proliferation, and differentiation. This study aims to evaluate the efficacy of PRF in improving the clinical periodontal parameters and GCF level of PDGF-BB.
详细描述
Split mouth randomized clinical trial is the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets will be designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites were treated by scaling and root planing only. Clinal periodontal parameters were recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •periodontitis
排除标准
- •Periodontal therapy for the last 3 months
- •Medical history of systemic diseases such as diabetes.
- •Patients wearing dental prosthesis
- •Alcoholic patients
- •Teeth with grade II mobility, endodontic lesions, and teeth with untreated caries
结局指标
主要结局
Change in Periodontal pocket depth measured in mm
时间窗: Change from baseline to 1-month and change from baseline to 3-month
Using UNC-15 periodontal probe measured in mm
Change in Clinical attachment level
时间窗: Change from baseline to 1-month and change from baseline to 3-month
Using UNC-15 periodontal probe measured in mm
次要结局
- Change in plaque index(Change from baseline to 1-month and change from baseline to 3-month)
- Change in bleeding on probing percentage(Change from baseline to 1-month and change from baseline to 3-month)
- Change in GCF level of platelet derived growth factor(Change from baseline to 1-month and change from baseline to 3-month)
研究者
Sarah Alrihaymee
Principal Investigator
University of Baghdad