Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Not Applicable

Completed

• Conditions: Postoperative Complications
• Interventions: Drug: Morphine Sulfate; Drug: Bupivacaine Hydrochloride

• Registration Number: NCT02962024
• Lead Sponsor: Fatma Adel El sherif,MD

Brief Summary

the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with breast cancer with assessment of its serum level if it will be absorbed systemically or not?

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-11-07
• Study First Submitted QC: 2016-11-10
• Study First Posted: 2016-11-11
• Primary Completion: 2018-05
• Study Completion: 2018-10
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-19
• Last Update Posted: 2020-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• (ASA) class I-II
• body weight of 50 - 90 kg

Exclusion Criteria

• a history of bleeding diathesis,
• relevant drug allergy, opioid dependence,
• sepsis, prior surgery in the supraclavicular, infraclavicular or axillary regions, alcohol or drug abuse , patients with advanced cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
morphine sulphate	Morphine Sulfate	10mg locally morphine hydrochloride once betwwen serratus muscle and latissmus dorsi muscle
bupivacaine hydrochloride	Bupivacaine Hydrochloride	0.25%locally bupivacaine hydrochloride once

Primary Outcome Measures

Name	Time	Method
serum morphine level after local injection	24 hours	concentration of serum morphine in ng/ml after local injection

Trial Locations

Locations (1)

South Egypt Cancer Instuite; 🇪🇬 Assuit, Egypt