Comparison of pre- and postoperative clinical target volumes at CT and MRI imaging in breast-conserving therapy: A prospective cohort study.

Completed

• Conditions: breast cancer; mammary malignancy; 10006291

• Registration Number: NL-OMON38406
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 27

Inclusion Criteria

- Female gender;
- Age >= 18 years,
- cT1-T2N0-1M0 breast cancer;
- Scheduled for breast-conserving therapy;
- Before breast-conserving surgery;
- Written informed consent.

Exclusion Criteria

- Legal incapability;
- Insufficient command of the Dutch language;
- History of ipsilateral breast surgery (benign, malign, augmentation, reduction);
- Inability to maintain the standard supine RT treatment position for 30 minutes;
- Exclusion criteria for MRI following the protocol of the department of radiology UMCU;
- GFR of <45mL/min/1.73m2. In patients with known risk factors a minimum GFR of <60mL/min/1.73m2 will be required, according to the UMCU protocol;
- Iodine allergy (contraindication for iodine-based intravenous contrast agents);
- Treated with neo-adjuvant chemotherapy.
- Treated with modified radical mastectomy.
- Treated with en-block axillary lymph node dissection.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Clinical target volumes pre-BCS and post-BCS on both CT and MR imaging.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable. </p><br>