NCT00702936Unknown4 期
Telmisartan vs Ramipril for Reduction of Inflammation and Recruitment of Endothelial Progenitor Cells After Acute Coronary Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- High sensitivity C-Reactive Protein
研究概览
简要总结
The purpose of this study is to compare the antinflammatory and endothelial progenitor cell (EPC) mobilizing effect of Ramipril and Telmisartan in patients presenting with acute coronary syndrome
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biochemical evidence of myocardial infarction as indicated by elevation of cTnT,
- •presence of ECG ischemic changes,
- •angiographic evidence of a primary coronary event, such as plaque erosion and/or rupture, fissuring, or dissection at coronary angiography,
- •successful coronary revascularization of at least one culprit coronary vessel.
排除标准
- •Age>80 years, current ACE inhibitor or ARB treatment,
- •ejection fraction <35%, infarction secondary to ischemia due to an imbalance of O2 supply and demand,
- •ECG abnormalities that could affect the recognition of ST segment shift,
- •recent or chronic infective or inflammatory diseases,
- •malignancy, and myocardial infarction,
- •surgery or trauma in the previous month.
研究组 & 干预措施
R
Active Comparator
Twenty-five patients assigned to ramipril 5 mg daily
干预措施: RAMIPRIL (Drug)
T
Active Comparator
Twenty-five patients assigned to Telmisartan 80 mg daily
干预措施: TELMISARTAN (Drug)
结局指标
主要结局
High sensitivity C-Reactive Protein
时间窗: 20 days after hospital discharge
次要结局
- Endothelial Progenitor Cells(20 days after hospital discharge)
研究者
研究点 (1)
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