Effect of Licorice and Hydrochlorothiazide on Plasma Potassium
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Plasma Potassium
研究概览
简要总结
This clinical trial is designed to study the effect of the combination of licorice and hydrochlorothiazide on plasma potassium levels in volunteers. In one arm, 10 healthy volunteers will be given 32 grams of licorice a day together with a 25 mg dose of daily hydrochlorothiazide for 14 days. This combination is compared with 32 grams of licorice a day for 14 days given in the other arm. The study is a randomized, open-label cross-over trial. There is at least a 3-week wash-out between the arms. The hypothesis is that the combination of licorice and hydrochlorothiazide will cause hypokalemia. The main outcome measure is the change in the plasma level of potassium between the arms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer
- •Age 18-40 years
排除标准
- •Any continuous medication
- •Any significant disease
- •Hypotension or hypertension
- •Allergy to licorice or hydrochlorothiazide
- •Pregnancy and breast feeding
- •Fear of needles and previous difficult blood samplings
- •Substance abuse
- •Participation in another clinical drug trial within 1 month of enrollment
研究组 & 干预措施
Licorice
干预措施: Licorice (Dietary Supplement)
Licorice and HCTZ
干预措施: Hydrochlorothiazide (Drug)
结局指标
主要结局
Plasma Potassium
时间窗: Baseline and 2 weeks
Plasma potassium measured with indirect ion specific electrode method
次要结局
未报告次要终点