Bright Light as a Countermeasure for Circadian Desynchrony
Not Applicable
- Conditions
- Healthy
- Interventions
- Other: Bright light
- Registration Number
- NCT01119365
- Lead Sponsor
- VA Palo Alto Health Care System
- Brief Summary
Light is the primary means by which the internal circadian clock remains aligned ("entrained") with the external world. Misalignment of this internal clock can occur during situations such as shift work and jet travel across multiple time zones (jet lag). The purpose of this study is to examine how sequences of brief flashes of light can affect entrainment of the clock.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Good health
- Normal hearing
Exclusion Criteria
- Sleep disorder
- Extreme chronotype
- Regular smoker
- Depression
- Alcohol abuse
- Illegal drug use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Light Bright light Sequence of bright light flashes of varying durations, interflash intervals, flash lengths, flash brightness, and flash color.
- Primary Outcome Measures
Name Time Method Circadian phase 2 days The timing of the onset of melatonin is compared before and after a light stimulus
- Secondary Outcome Measures
Name Time Method Alertness 1 hour Alertness as assessed through change in brain wave (electroencephalographic, EEG) activity, questionnaires, and objective testing is examined before and at the end of a light stimulus
Trial Locations
- Locations (1)
VA Palo Alto Health Care System
🇺🇸Palo Alto, California, United States