Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome
- Conditions
- Acute Coronary Syndrome
- Interventions
- Other: Circulating wnt 2 and wnt 4 concentration
- Registration Number
- NCT03342131
- Lead Sponsor
- The First Affiliated Hospital of Dalian Medical University
- Brief Summary
This study aims to find the change of serum wnt effectory moleculars and the association with Hs-CRP，cTnI and Prognosis in Patients with Acute Coronary Syndrome.
- Detailed Description
It has been reported that wnt effecory moleculars (wnt2, wnt4, wnt11,wnt10b, DKK1, DKK2) increased in myocardium at acute phase after myocardium infarction in animal experiment. These moleculars can be detected in serum or plasma from human subjects. However, there is few relevant studies about wnt2 and wnt4 concentration in patients with acute coronary syndrome. This study valuates the serum wnt2 and wnt4 concentration in patients with acute coronary syndrome. It will possibly enable to find the relationship between serum wnt2 or wnt4 concentration and Hs-CRP, cTnI and prognosis in patients with Acute Coronary Syndrome.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 450
.diagnosed as acute coronary syndrome, including STEMI and NST-ACS.
- with left ventricular ejection fraction（LVEF）>=45%
- written informed consents are obtained
- admitted within 24 hours after chest pain attacked
-
• complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- with acute or chronic infection, surgery or trauma in the last month
- secondary hypertension, severe liver dysfunction,severe renal insufficiency
- with abnormal thyroid function or allergy to iodine agent refusal to sign the informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control group Circulating wnt 2 and wnt 4 concentration 150 age and body mass index matched healthy subjects with neither coronary artery disease nor any of the components of the metabolic syndrome are studied as Control group. Circulation wnt2 and wnt4 concentration in Control group will be measured only once with 24h after admission. NST-ACS group Circulating wnt 2 and wnt 4 concentration The study population consists of 150 patients with non-ST elevated acute myocardial infarction (NST-ACS) including unstable angina pectoris (UAP),who are admitted within 24 hours after chest pain attack. They will all undergo coronary angiography. The diagnosis is made according to American Heart Association (AHA, 2014 and 2015) guidelines. Patients who had autoimmune diseases, malignancies, chronic or acute infections, asthma, severe heart failure (NYHA class 3 and 4) and advanced liver or renal diseases are excluded.Blood (150 each group) is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture to explore circulating wnt 2 and wnt 4 concentration by ELISA at 0 , 7days and 12 months after admission. STEMI group Circulating wnt 2 and wnt 4 concentration The study population consists of 150 patients with ST-elevated acute myocardial infarction (STEMI) who are admitted within 24 hours after chest pain attack. They will all undergo coronary angiography. The diagnosis is made according to American Heart Association (AHA, 2014 and 2015) guidelines. Patients who had autoimmune diseases, malignancies, chronic or acute infections, asthma, severe heart failure (NYHA class 3 and 4) and advanced liver or renal diseases are excluded. Blood (150 each group) is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture to explore circulating wnt 2 and wnt 4 concentration by ELISA at 0 , 7days and 12 months after admission.
- Primary Outcome Measures
Name Time Method Serum wnt2 and wnt4 concentration 12 months Serum wnt2 and wnt4 concentration in ng/ml
- Secondary Outcome Measures
Name Time Method Relationship between wnt2 or wnt4 and high sensitive C reaction protein (hs-CRP) concentration 12 months Correlation of wnt2 and wnt4 with hs-CRP concentration
Relationship between wnt2 or wnt4 and Troponin-I (Tn-I) concentration 12 months Correlation of wnt2 and wnt4 with Tn-I concentration
MACEs during 12-month follow-up 12 months Association of wnt2 or wnt4 concentration with prognosis
Trial Locations
- Locations (1)
The First Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China