Study of thickness of blood supply layer within the eye in children with one eye being lazy using scan machine , before and after treatment for lazy eye.

Not yet recruiting

Conditions: Amblyopia ex anopsia,

Registration Number: CTRI/2020/09/028092

Lead Sponsor: Sankara Eye Hospital Shimoga

Brief Summary: Amblyopia is defined as decrease of visual acuity in one eye when caused by abnormal binocular interaction or occurring in one or both eyes as a result of pattern vision deprivation during visual immaturity, for which no cause can be detected during the physical examination of the eye (s) and which in appropriate cases is reversible by therapeutic measures.

Choroid is the posterior most part of the uveal tissue and has maximum vascular supply per unit mass in the eye.

Optical Coherence Tomography (OCT) is non-invasive technique allowing high resolution, cross sectional tomographic images of choroid, retina, optic nerve and its layers.

It is based on low coherence interferometry typically employing near infrared light.

OCT measures choroidal thickness (CT), macular thickness(MT), peripapillary retinal nerve fibre layer thickness (RNFLT). Macular vascular density (MVD) is measured by OCT Angiography

(OCTA).

Occlusion therapy has long been the mainstay of amblyopia treatment.

Various studies are available documenting changes in choroidal thickness (CT), macular thickness (MT), foveal thickness(FT) and retinal nerve fibre thickness (RNFLT) in amblyopic eyes.

However, there are only few studies available on analysis of these parameters following occlusion therapy.

Hence, the purpose of our study is not only to analyse structural changes in choroidal , macular , peripapillary RNFLT and macular vascular density in unilateral amblyopic eyes and compare the same

with normal fellow eye and normal eyes of normal children but also to understand the same following occlusion therapy.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Children with unilateral strabismic and anisometropic amblyopia will be included in group 1.
Uncorrected visual acuity of LogMAR 0.00 in both eyes will be included in group 2.
Children with normal neurological, ocular and systemic examination.
Children who will be willing for follow up.

Exclusion Criteria

1.Previous history of Spectacle wear/ Occlusion therapy/ Ocular surgery.
2.Refractive error correction >6D Spherical power and >3D Cylindrical power.
Presence of Nystagmus/ Hearing impairment/ Development delay.
Not compliant for Spectacle wear and/ or occlusion therapy.
Children who will have poor fixation co-operation for SS-OCT test due to poor vision or lower age.
Children who will come for <2 follow up.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analysis of Choroidal thickness changes in children with unilateral amlyopia	at presentation(baseline) and on follow up visits of 3rd, 6th and 12th month.

Secondary Outcome Measures

Name	Time	Method
1. Analysis of macular thickness, peripapillary retinal nerve fibre layer thickness and macular vascular density changes in children with unilateral amblyopia .	On presentation (baseline) and follow up visits of 3rd, 6th and 12th month.
2. Study of occlusion therapy on the choroidal thickness, macular thickness, peripapillary retinal nerve fibre layer thickness and macular vascular density.	On follow up visits of 3rd, 6th and 12th month

Trial Locations

Locations (1): Sankara Eye Hospital
🇮🇳
Shimoga, KARNATAKA, India
Sankara Eye Hospital
🇮🇳Shimoga, KARNATAKA, India
Dr Shrutika Baburao Bhimewar
Principal investigator
8275940851
sbb239@gmail.com