Molecular Characterization of Induced Neuronal Cells Derived From Fibroblasts of Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Neurophysiological characterization of dopaminergic neurons derived from patients with Parkinson's disease.
研究概览
简要总结
To describe the molecular, electrophysiological and morphological expression profile of dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects aged 18 years or older
- •Patients with Parkinson's disease, according to the most recent diagnostic criteria
- •Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study
排除标准
- •Patients affected by drug-induced parkinsonism or atypical parkinsonian disorders
- •Patients with neurological diseases other than Parkinson's disease
- •Inability to sign an informed consent
- •Severe psychiatric diseases
结局指标
主要结局
Neurophysiological characterization of dopaminergic neurons derived from patients with Parkinson's disease.
时间窗: Baseline
To evaluate the firing frequency in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
Biochemical characterization of dopaminergic neurons derived from patients with Parkinson's disease.
时间窗: Baseline
To determine the amount of dopamine released from differentiated neurons derived from fibroblasts of patients with Parkinson's disease.
α-synuclein misfolding in dopaminergic neurons derived from patients with Parkinson's disease.
时间窗: Baseline
To document the presence of abnormal accumulation of misfolded alpha-synuclein in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
次要结局
未报告次要终点