Developing a Risk Assessment System of Multidrug-resistant Organisms Infection

Completed

• Conditions: Bacterial Infections
• Interventions: Other: risk factors of infection with multidrug-resistant organisms

• Registration Number: NCT04688216
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

1. A retrospective analysis was performed to determine the prevalence of multidrug- resistant organisms infection in ICU from October 2017 to October 2019.

2. Non-MDRO patients were selected by random sampling in a ratio of 1:1 to the final MDRO group during the same period , and select the risk factors of infection with multi-drug resistant bacteria by comparing the two groups.

3. Randomly select 30% of the sample size as the validation set, and the remaining 70% for the training set to establish a model. Using multi-factor Logistic regression, decision tree classification, artificial neural network, support vector machine, Bayesian network Method to establish risk assessment system for multidrug-resistant organisms infection respectively.Using validation set data to calculate the area under the ROC curve (AUC) and sensitivity, specificity of models and comparing the prediction accuracy of several models. Finally, choose a more suitable risk assessment system for multidrug-resistant organisms infection.

4. Predict the patient's infection risk level according to the best risk assessment system and develop a low-to-high intervention plan.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2020-12-06
• Study First Submitted QC: 2020-12-24
• Study First Posted: 2020-12-29
• Primary Completion: 2022-05-01
• Status Verified: 2022-12
• Study Completion: 2022-12-30
• Last Update Submitted: 2023-05-24
• Last Update Posted: 2023-05-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 917

Inclusion Criteria

Not provided

Exclusion Criteria

• Patients with MDRO infection at the time of admission
• Lack of case data
• MDRO colonized patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-MDRO	risk factors of infection with multidrug-resistant organisms	-
MDRO	risk factors of infection with multidrug-resistant organisms	-

Primary Outcome Measures

Name	Time	Method
multidrug-resistant organisms infection	From date of ICU admissions until the date of ICU discharge or date of diagnosis of multidrug-resistant organisms infection , whichever came first, assessed up to 24 months	Ratio of the number of multi-drug resistant bacterial infections to the total number of patients

Trial Locations

Locations (1)

2nd Affiliated Hospital, School of Medicine, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China