Using Sensors to Measure Drug Concentrations in Exhaled Breath
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Correlation between drug concentration and volatile organic compounds VOC concentrations
研究概览
简要总结
The use of blood tests to measure drug concentrations in psychiatric patients is often a crucial part of monitoring and evaluating the course of treatment. Such tests are commonly conducted as part of official protocols, and patients are often tested on a weekly basis.
The current study aims to examine the possibility of using a novel, non-invasive device to measure drug concentrations in exhaled breath as an alternative to blood tests. The device, SniffPhone, uses sensors to detect and measure volatile organic compounds (VOCs) in exhaled breath, and features a small and portable design. Sniff Phone has been previously approved for use in clinical trials and has been used successfully to screen for particular types of cancer and other diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Proper ability to give informed consent
- •Psychiatric patients undergoing treatment at Sheba Medical Center
- •Patients with treatment plans that require therapeutic drug monitoring
排除标准
- •Involuntary psychiatric hospitalization
- •Pregnancy
结局指标
主要结局
Correlation between drug concentration and volatile organic compounds VOC concentrations
时间窗: Up to 6 months
Correlation between drug concentration (as measured in blood test) and VOCs (hexanone acetic acid, heptane, hexanal, 3-heptanone, hexanoic acid, heptanal and nonanal) measured using Sniff Phone.
Detection of drug type and concentration in volatile organic compounds (VOCs) profile
时间窗: Up to 6 months
Detection of drug type and concentration in VOCs profile (measured using Sniff Phone)
次要结局
未报告次要终点
研究者
Nadav Goldental
Principal investigator
The Chaim Sheba Medical Center