The Effects of a High-quality Vegan Diet on Skeletal Muscle Maintenance and Adaptation in Comparison to a Protein-matched Omnivorous Diet in Healthy Older Adults.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis (MPS) in resting and exercised tissue
研究概览
简要总结
Dietary protein intake and physical activity are key to minimise the age-related loss of skeletal muscle mass. While animal-derived protein sources are considered high-quality anabolic foods, it remains unclear whether non-animal-derived (vegan) protein sources support skeletal muscle maintenance and healthy ageing. The aim of the present study is to assess the effect of a vegan diet on daily muscle protein synthesis rates compared to a protein-matched omnivorous diet where the majority of protein is derived from high-quality animal-based protein sources.
详细描述
Background: The age-related loss of muscle mass and strength is (partly) explained by a blunted responsiveness of skeletal muscle to the anabolic properties of dietary protein and muscle contraction. Therefore, sufficient dietary protein intake and physical activity are required to minimise age-related muscle atrophy. It remains unknown whether this can be achieved utilising non-animal-derived (vegan) protein sources.
Objective
To assess daily muscle protein synthesis rates when adopting a vegan or protein-matched omnivorous control diet.
Methods: Healthy older adults (aged 60-80 years) will be randomly allocated to a completely controlled 1-week vegan (providing 0.8 g/kg BW/day protein) or protein-matched omnivorous diet. During this week, participants will perform a set of unilateral leg resistance exercise on day 1, 3, and 5. Deuterium oxide in combination with saliva and muscle sample (from the m. vastus lateralis) collection will be used to measure daily muscle protein synthesis rates in resting and exercised tissue.
Value: This will be the first study assessing daily muscle protein turnover in healthy older adults adopting a 1-week vegan diet. This will contribute to the understanding and viability of vegan protein to support active and healthy ageing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 18.5 - 30
- •Active (not very sedentary and not master athlete; assessed via IPAQ)
- •Women only: post menopause
排除标准
- •Hypertension (>150/90 mmHg)
- •Any diagnosed metabolic impairment
- •Any diagnosed cardiovascular disease
- •Any diagnosed gastrointestinal disease
- •Diagnosed cancer
- •Any medication known to affect muscle metabolism (e.g. hormone replacement therapy)
- •Severe food allergies or intolerances (e.g. celiac, lactose intolerance, allergic to fungi or algae foods)
结局指标
主要结局
Muscle protein synthesis (MPS) in resting and exercised tissue
时间窗: 7 days
Daily MPS rates, expressed as fractional synthetic rate (%/h)
次要结局
- Muscle morphology(7 days)