Vegan Diets: the short-term effects on daily muscle protein synthesis rates as compared to omnivorous diets in Older adults assessed by D2O.

Completed

• Conditions: glucose- en lipidenmetabolismestoornissen; age-related muscle loss; Sarcopenia; 10003018; 10028302

• Registration Number: NL-OMON51234
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Aged 65-79 years
Community-dwelling
Body Mass Index (BMI) 20-35 kg/m2

Exclusion Criteria

- Following a vegetarian or vegan diet during the six months prior to the study;
- Following a diet that affects protein intake during the six months prior to
the study;
- >=5% of body weight loss during three months before the start of the study;
- Participating in a structured exercise training program in the past 3 months;
- Being diagnosed with one of the following: diabetes; renal disease;
neurological or neuromuscular disorders; serious cardiovascular diseases;
cancer; chronic obstructive lung disease (COPD);
- Chronic use of medication that affects muscle function, e.g. corticosteroids,
metformin, insulin;
- The use of the following medicines: acenocoumarol (sintrom); phenprocoumon
(marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto);
clopidogrel (plavix); combination of acetylsalicylic acid or carbasalate
calcium (ascal) with dipyridamole.
- Allergic or intolerant to any product included in the diets;
- Not willing to stop nutritional supplements, with the exception of
supplements on medical advice, and vitamin D;
- Not willing or afraid to give blood or undergo a muscle biopsy during the
study;
- Unwilling to eat a vegan and an omnivorous diet for ten days each;
- Not vaccinated for COVID-*19;
- Currently a research subject in another trial or participated in a clinical
trial during 3 months before the start of the measurement period;
- Not being able to understand Dutch;
- Not having a general physician.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter includes the difference in muscle fractional<br /><br>synthesis rates (FSR; %/day) between the vegan diet and omnivorous diet. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include the difference in satiety, blood pressure,<br /><br>plasma blood glucose, insulin and lipid profile (HDL; LDL; cholesterol;<br /><br>triglycerides) between the vegan and the omnivorous diet.</p><br>