The effects of a short-term vegan diet on metabolic and inflammatory parameters in healthy older adults: randomized, controlled intervention study in a cross-over desig
Not Applicable
- Conditions
- INFLAMMATIONmetabolism
- Registration Number
- DRKS00025433
- Lead Sponsor
- Charité Campus Virchow-Klinikum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Age = 65 to 80 years
- MMSE = 24 points
- No severe cardiac (up to NYHA II) and renal insufficiency (GFR> 30 ml / min)
- no liver insufficiency and - cirrhosis
- No severe COPD (stages I to II)
- No tumor diseases
Exclusion Criteria
- Age <65 or> 80 years
- MMSE <24
- BMI <22 kg / m² and BMI = 30 kg / m²
- Special diets (vegetarian, vegan, low-carbohydrate / ketogenic, weight reduction programs, forms of fasting)
- Unintentional weight loss in the last six months (= 5%)
- food allergies
- Severe cardiac (from NYHA III) or renal insufficiency (GFR <30 ml / min)
- Liver insufficiency and liver cirrhosis (Child Pugh Score A - C)
- Severe COPD (stage III to IV)
- Existing oncological disease
- Diabetes mellitus requiring treatment
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant differences in triglyceride concentrations in blood serum in the intervention group of 0.65 mmol / l and in the control group of 1.025 mmol / l after 48 hours of vegan diet modification.
- Secondary Outcome Measures
Name Time Method Short-term vegan nutritional intervention can reduce the pro-inflammatory status in healthy, older subjects.