Effect of Galactose Ingestion on Postprandial Lipemia

Not Applicable

Completed

• Conditions: Lipemia; Cardiovascular Risk Factor
• Interventions: Dietary Supplement: Galactose; Dietary Supplement: Glucose

• Registration Number: NCT03439878
• Lead Sponsor: University of Bath

Brief Summary

This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2018-02-14
• Study First Submitted QC: 2018-02-14
• Study First Posted: 2018-02-20
• Status Verified: 2018-05
• Primary Completion: 2018-05-01
• Study Completion: 2018-05-01
• Last Update Submitted: 2018-05-23
• Last Update Posted: 2018-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Male
• 18 to 35 years old
• Body mass index <30 kg/m2

Exclusion Criteria

• Female
• Body mass index >29.9 kg/m2
• Any history of metabolic disease
• Allergies or intolerances to milk and/or cream

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Galactose	Galactose	Ingestion of 0.75 g/kg body mass of d-galactose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat.
Glucose	Glucose	Ingestion of 0.75 g/kg body mass of dextrose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat.

Primary Outcome Measures

Name	Time	Method
Postprandial increase plasma triglyceride concentrations	5 hours	Incremental area under the curve (iAUC) of plasma triglyceride concentrations

Secondary Outcome Measures

Name	Time	Method
Postprandial plasma glucose concentrations	5 hours	Incremental area under the curve (iAUC) of plasma glucose concentrations
Postprandial overall appetite ratings	5 hours	Postprandial area under the curve of overall appetite ratings measured by visual analogue scales (0-100 mm)
Postprandial plasma lactate concentrations	5 hours	Incremental area under the curve (iAUC) of plasma lactate concentrations
Postprandial prospective food consumption ratings	5 hours	Postprandial area under the curve of prospective food consumption ratings measured by visual analogue scales (0-100 mm)
Postprandial plasma insulin concentrations	5 hours	Incremental area under the curve (iAUC) of plasma insulin concentrations
Postprandial subjective hunger ratings	5 hours	Postprandial area under the curve of hunger ratings measured by visual analogue scales (0-100 mm)
Postprandial plasma non-esterified fatty acid concentrations	5 hours	Postprandial area under the curve of non-esterified fatty acid concentrations
Postprandial subjective fullness ratings	5 hours	Postprandial area under the curve of fullness ratings measured by visual analogue scales (0-100 mm)
Postprandial subjective satisfaction ratings	5 hours	Postprandial area under the curve of satisfaction ratings measured by visual analogue scales (0-100 mm)

Trial Locations

Locations (1)

Department for Health, University of Bath; 🇬🇧 Bath, United Kingdom