Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging

Completed

• Conditions: Myocardial Infarction
• Interventions: Radiation: Computed tomography late enhancement imaging

• Registration Number: NCT02364687
• Lead Sponsor: University of Edinburgh

Brief Summary

Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2015-02-10
• Study First Submitted QC: 2015-02-10
• Study First Posted: 2015-02-18
• Primary Completion: 2015-12
• Status Verified: 2022-06
• Study Completion: 2023-05
• Last Update Submitted: 2023-06-26
• Last Update Posted: 2023-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Presence of late enhancement on magnetic resonance imaging

Exclusion Criteria

• age less than 40
• inability or unwillingness to undergo CT
• renal failure (serum creatinine >200 umol/l or estimated glomerular filtration rate <30 ml/min)
• hepatic failure
• allergy to iodinated contrast
• pregnancy
• breast feeding
• inability to undergo informed consent
• fast atrial fibrillation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Participants	Computed tomography late enhancement imaging	Participants will have previously had an MRI scan and will undergo a CT scan.

Primary Outcome Measures

Name	Time	Method
Myocardial late enhancement	Immediate	The amount of myocardial late enhancement measured on computed tomography as compared to magnetic resonance imaging.