Can a high fibre diet reduce the amount of insulin the body needs to process the sugar consumed in meals?
Not Applicable
Completed
- Conditions
- Insulin resistance in a population with a high rate of obesityMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12609000888268
- Lead Sponsor
- niversity of Auckland / Liggins Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria
15 - 16 year old males from low socio-economic areas.
Exclusion Criteria
Receiving medications that influence insulin sensitivity (SI) (incluing oral steroids and metformin).
Genetic conditions, (Turner, Downs or Prader-Willi syndrome).
Coeliac disease or other malabsorption disorders.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insulin sensitivity. This will meaured through the matsuda method which is the best model to the gold standard euglycaemic clamp. This involved overnight fasting, with a oral glucose tolerance test, with measurements at 0min, 30 min, 60, 90 and 120 of serum insulin and glucose. That matsuda index calculation gives an insulin sensitivity score.<br> Equipment will be IV cannulation, and syringes to draw the venous samples at the time points as described above. The Liggins Institute has an in house assay for insulin levels.[Baseline, 6 week cross over, and completion (14 weeks)]
- Secondary Outcome Measures
Name Time Method Body Mass Index[Baseline, 6 week cross over, and completion (14 weeks)];Blood pressure. This will be through 24hour ambulatory blood pressure monitoring.[Baseline, 6 week cross over, and completion (14 weeks)]