Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

Not Applicable

Completed

• Conditions: Aging; Muscle Hypertrophy

• Registration Number: NCT06718712
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

Detailed Description

The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Study Timeline

• Study Start: 2018-04-01
• Primary Completion: 2018-12-20
• Study Completion: 2018-12-20
• Status Verified: 2024-11
• Study First Submitted: 2024-12-01
• Study First Submitted QC: 2024-12-01
• Study First Posted: 2024-12-05
• Last Update Submitted: 2024-12-05
• Last Update Posted: 2024-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• 60 years and older
• not engaged in regular resistance and/or aerobic training for at least six months before the intervention

Exclusion Criteria

• diagnosed type I diabetes mellitus
• arrhythmia
• noncontrolled hypertension
• any major orthopedic musculoskeletal condition
• use of any dietary supplement or drug with potential anabolic effects

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Quadriceps muscle cross-sectional area	10 weeks	Quadriceps muscle CSA was obtained through magnetic resonance imaging.

Secondary Outcome Measures

Name	Time	Method
Maximum dynamic strength	10 weeks	Unilateral quadriceps 1-RM of both legs were assessed on a knee-extension machine

Trial Locations

Locations (1)

University of Sao Paulo; 🇧🇷 Sao Paulo, SP, Brazil