Employing combined neuroimaging techniques and CSF biomarkers to characterise spatiotemporal dynamics in Dementia and Mild Cognitive Impairment

Cognetivity Limited0 sites90 target enrollmentFebruary 15, 2018

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Alzheimer's Dementia, Mild Cognitive Impairment, Mild Cognitive Disorder
Sponsor: Cognetivity Limited
Enrollment: 90
Status: Completed
Last Updated: 8 years ago

No summary available.

Registry

who.int

Start Date

February 15, 2018

End Date

February 1, 2019

Last Updated

8 years ago

Study Type

Interventional

Sex

All

Sponsor

Cognetivity Limited

•Control group:
•1\. Addenbrooke’s Cognitive Examination (Revised/III) score of above 84
•2\. Bristol Activities of Daily Living Scale score of unimpaired” or mildly impaired”
•3\. Capacity to understand the information about the study and to give consent to participate
•4\. Males and females aged between 65\-80 years
•5\. Not currently on medication that may interfere with the study results
•6\. In good general health
•7\. Matched for age and education
•1\. A clinical diagnosis of MCI according to ICD\-10 criteria, diagnosed by an Old Age Psychiatrist
•2\. Mini Mental State Examination (MMSE) \<28 and \> 24

•Control group
•1\. Presence of significant cerebrovascular disease ie. History of CVA
•2\. Major medical co\-morbidities e.g. Congestive Cardiac Failure, Diabetes Mellitus with renal impairment
•3\. Major psychiatric disorder eg. Chronic psychosis, recurrent depressive disorder, generalized anxiety disorder
•4\. The use of cognitive enhancing drugs e.g. cholinesterase inhibitors
•5\. A concurrent diagnosis of epilepsy
•6\. A history of alcohol misuse
•7\. A history of illicit drug use
•8\. A history of severe visual impairment, e.g. macular degeneration, diabetic retinopathy, as determined by the clinical team
•9\. A history of repeated head trauma