To compare the effects of intravenous dexmedetomidine and magnesium sulphate given in addition to general anaesthesia on perioperative haemodynamics in patients undergoing laparoscopic cholecystectomy

Not Applicable

Completed

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2023/04/051448

Lead Sponsor: Pt B. D. Sharma University Of Health Sciences, PGIMS,Rohtak, Haryana

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 69

Inclusion Criteria

American society of Anesthesiology grade I and II between the age of 18-65 years, of either sex and posted for laparoscopic cholecystectomy under general anaesthesia

Exclusion Criteria

Patients with major hepatic, renal and endocrine dysfunction, cardiovascular dysfunction; neuromuscular, neurological disorder, atrioventricular conduction disturbance, COPD, asthma, obstructive sleep apnea and haematological disorders.

Patients with difficult airway.

Patients with known allergy to dexmedetomidine or magnesium sulphate.

Pregnancy, obesity (body mass index >30 kg m-2), hypertension, diabetes mellitus, and

major systemic illness

Patients on treatment with calcium channel blockers, beta-blockers, alpha 2 adrenergic agonists or

opioid abuse

Any intraoperative surgical complication like prolonged surgery (duration more than

two hours) or conversion to open surgery,

Patient’s unwillingness to participate in the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the changes in HR & MAP during laryngoscopy and intubation, creation & release of pneumoperitoneum and extubation.Timepoint: T0 baseline data <br/ ><br>T1 following completion of study drug infusion <br/ ><br>T2 1 minute after induction <br/ ><br>T3 1 minute after intubation <br/ ><br>T4 after peritoneal insufflation <br/ ><br>T5 15 min after peritoneal insufflation T6 after peritoneal deflation <br/ ><br>T7 1 min after extubation <br/ ><br>T8 60 min after extubation

Secondary Outcome Measures

Name	Time	Method
To observe and compare intraoperative anaesthesia requirement, extubation time, time to first rescue analgesic requirement and postoperative sedationTimepoint: Intraop requirement of total propofol, fentanyl, muscle relaxant and mean end tidal sevoflurane concentration ;Extubation time; Duration of surgery; Time to first rescue analgesia- time from extubation to time when pain reported by patient was =4 on visual analogue scale. Injection paracetamol l5mg/kg IV will be used ,If the patient doesn’t get relief in 15 min Injection diclofenac 1.5mg/kg will be given; Post op sedation level will be assessed at 1,15,30, 60 min using Ramsay sedation score <br/ ><br>