Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

Completed

• Conditions: Heart Arrest; Cardiac Arrest

• Registration Number: NCT01968148
• Lead Sponsor: Helsinki University Central Hospital

Brief Summary

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-10-19
• Study First Submitted QC: 2013-10-22
• Study First Posted: 2013-10-23
• Study Start: 2013-11
• Primary Completion: 2015-07-30
• Study Completion: 2015-07-30
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-11
• Last Update Posted: 2018-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age ≥18 years
• witnessed cardiac arrest
• interval form emergency call to return of spontaneous circulation 10-45 minutes

Exclusion Criteria

• severe pre-arrest disability leading to withdrawing treatment in prehospital phase
• no concent from next of kin

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in level of insulin	60 minutes
Change in level of glucagon	60 minutes

Secondary Outcome Measures

Name	Time	Method
Blood cortisol level	60 minutes after ROSC
Blood interleukin-6 level	60 minutes after ROSC
Change in level of GLP-1	60 minutes
Change in blood glucose level	60 minutes

Trial Locations

Locations (2)

Helsinki Emergency Medical Services; 🇫🇮 Helsinki, Finland

Helsinki Area Helicopter Emergency Medical Services; 🇫🇮 Vantaa, Finland