Identifying protein profile differences between laryngeal cancer of young and elderly patients: a pilot study.
Completed
- Conditions
- cancer of the voice boxlaryngeal cancer1003866610029107
- Registration Number
- NL-OMON40763
- Lead Sponsor
- niversitair Medisch Centrum Groningen (UMCG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Newly diagnosed squamous cell laryngeal cancer;
Malignancy limited to one side of the larynx;
Age <65 years (n=10) or age >=75 years (n=10);
Written informed consent;
WHO performance status 0-2.
Exclusion Criteria
Age >= 65 years and < 75 years;
Previous treatment of laryngeal cancer;
Previous radiation therapy in head and neck area;
Diagnostig laryngoscopy in emergency situation.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Identification of protein profile differences between laryngeal cancers of<br /><br>young and elderly patients, by comparing differential expression of proteins in<br /><br>cancer and healthy tissue of the same patients, determined by Liquid<br /><br>Chromatography Tandem Mass Spectometry (LC-MS/MS) using the Orbitrap/qTOF mass<br /><br>analyzer.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Identification of differences between protein interaction network in cancer and<br /><br>healthy tissue between elderly and young laryngeal cancer patients, determined<br /><br>by Liquid Chromatography Tandem Mass Spectometry (LC-MS/MS) using the<br /><br>Orbitrap/qTOF mass analyzer.</p><br>