ISRCTN68849312已完成不适用
Reversal of cerebrovascular endothelial dysfunction in diabetes: the effect of allopurinol upon cerebrovascular nitric oxide bioavailability
Greater Glasgow NHS Board/Glasgow University (UK)0 个研究点目标入组 24 人开始时间: 2005年11月22日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Type II diabetes less than 5 years duration, treated with diet, metformin thiazolidinediones or a combination
- •2. Aged greater than 40 years
- •3. Normal full Bruce protocol exercise treadmill testing (ETT)
- •4. Favourable temporal bony window
- •5. HbA1c less than 9%
- •6. Cholesterol less than 7.5 mmol/l
排除标准
- •1. Greater than 70% Internal carotid artery stenosis
- •2. Known coronary artery disease
- •3. Other significant comorbidity
- •4. Contraindication to allopurinol
- •5. Concurrent therapy with azathioprine or 6-mercaptopurine
- •6. Insulin or sulphonylurea treatment
- •7. Serum creatinine greater than 250 µmol/l
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