EUCTR2005-001670-27-GB
Active, not recruiting
Not Applicable
Reversibility of cerebrovascular endothelial dysfunction in diabetes: the role of allopurinol.
Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship0 sites24 target enrollmentOctober 17, 2005
ConditionsType Two Diabetes Mellitus
DrugsAllopurinol
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type Two Diabetes Mellitus
- Sponsor
- Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship
- Enrollment
- 24
- Status
- Active, not recruiting
- Last Updated
- 14 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type II diabetes of less than 5 years' duration treated with diet, metformin, thiazolidinediones or a combination of above
- •Age \> 40 years
- •Normal full Bruce protocol exercise tolerance test
- •Favourable temporal bony window
- •Stable glycaemic control (HbA1c \< 9\.0%)
- •Stable cholesterol (total cholesterol \< 7\.5
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range
Exclusion Criteria
- •\>70% extra\-cranial internal carotid artery stenosis
- •Known coronary arterial disease
- •Significant co\-morbidity
- •Contra\-indication to or indication for administration of allopurinol
- •Concurrent azathioprine or 6\-mercaptopurine therapy
- •Insulin or sulphonylurea therapy
- •Serum creatinine concentration greater than 250 micromoles per litre
Outcomes
Primary Outcomes
Not specified
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