Histamine H1/H2 Receptors and Training Adaptations
- Conditions
- Exercise TrainingPhysical Activity
- Interventions
- Other: LactoseOther: High-intensity interval training (HIIT)
- Registration Number
- NCT04450134
- Lead Sponsor
- University Ghent
- Brief Summary
Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 19
- Sedentary or low levels of physical activity
- Caucasian
- Chronic diseases
- Medication use
- Smoking
- Excessive alcohol consumption
- Seasonal allergies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo High-intensity interval training (HIIT) 6 weeks high-intensity interval training + placebo intake Placebo Lactose 6 weeks high-intensity interval training + placebo intake Blockade High-intensity interval training (HIIT) 6 weeks high-intensity interval training + histamine H1/H2 receptor blockade Blockade Fexofenadine Hydrochloride 6 weeks high-intensity interval training + histamine H1/H2 receptor blockade Blockade Famotidine 6 weeks high-intensity interval training + histamine H1/H2 receptor blockade
- Primary Outcome Measures
Name Time Method Change in cardiorespiratory fitness Before, after 3 weeks and after 6 weeks of exercise training Change in maximal oxygen uptake during incremental cycling test on cycle ergometer during the 6 week training period
Change in peak aerobic power output Before, after 3 weeks and after 6 weeks of exercise training Change in peak power output during incremental cycling test on cycle ergometer during the 6 week training period
Change in whole-body insulin sensitivity Before and after 6 weeks of exercise training Change from baseline in Matsuda index for whole-body insulin sensitivity derived from Oral Glucose Tolerance Test after the 6 week training period
Change in microvascular function Before and after 6 weeks of exercise training Change from baseline in microvascular function (Single Passive Leg Movement technique) after the 6 week training period
- Secondary Outcome Measures
Name Time Method Change in substrate oxidation during submaximal cycling Before and after 6 weeks of exercise training Change from baseline in substrate oxidation during submaximal cycling test (estimated via gas exchange data) after the 6 week training period
Change in blood lactate accumulation during submaximal cycling Before and after 6 weeks of exercise training Change from baseline in capillary lactate concentration at end of submaximal cycling test after the 6 week training period
Change in fasted serum glucose concentrations Before and after 6 weeks of exercise training Change from baseline in fasted blood concentrations of glucose after the 6 week training period
Change in body weight Before and after 6 weeks of exercise training Change from baseline in total body weight after the 6 week training period
Change in skeletal muscle protein content Before and after 6 weeks of exercise training Change from baseline in Western Blot assessment of markers of relevance for skeletal muscle function after the 6 week training period
Change in skeletal muscle capillarization Before and after 6 weeks of exercise training Change from baseline in skeletal muscle capillarization (immunohistochemistry) after the 6 week training period
Change in power output at Gas Exchange Threshold (GET) Before, after 3 weeks and after 6 weeks of exercise training Change from baseline in GET during incremental cycling test after the 6 week training period
Change in skeletal muscle enzyme activity Before and after 6 weeks of exercise training Change from baseline in enzyme activity assessment of markers of relevance for skeletal muscle function after the 6 week training period
Change in power output at Respiratory Compensation Point (RCP) Before, after 3 weeks and after 6 weeks of exercise training Change from baseline in RCP during incremental cycling test after the 6 week training period
Change in time to exhaustion performance test Before, after 3 weeks and after 6 weeks of exercise training Change in time to exhaustion test (performed after incremental cycling test) during the 6 week training period
Change in heart rate during submaximal cycling Before and after 6 weeks of exercise training Change from baseline in heart rate during submaximal cycling after the 6 week training period
Change in cycling efficiency during submaximal cycling Before and after 6 weeks of exercise training Change from baseline in cycling efficiency (estimated via gas exchange data) after the 6 week training period
Change in fasted serum insulin concentrations Before and after 6 weeks of exercise training Change from baseline in fasted blood concentrations of insulin after the 6 week training period
Change in fasted serum cholesterol concentrations Before and after 6 weeks of exercise training Change from baseline in fasted blood concentrations of cholesterol after the 6 week training period
Change in fasted serum triglyceride concentrations Before and after 6 weeks of exercise training Change from baseline in fasted blood concentrations of triglyceride after the 6 week training period
Change in resting heart rate Before and after 6 weeks of exercise training Change from baseline in resting heart rate after the 6 week training period
Change in resting blood pressure Before and after 6 weeks of exercise training Change from baseline in resting mean arterial blood pressure after the 6 week training period
Trial Locations
- Locations (1)
Department of Movement and Sports Sciences, Ghent University
🇧🇪Gent, Oost-Vlaanderen, Belgium