Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Ischemic Stroke
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Changes of glial lymphatic system
研究概览
简要总结
Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient was 18-80 years old;
- •The NIHSS score was ≤ 25 and NIHSS > 5，Glasgow coma score ≥ 8;
- •The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset
- •Normal to random time within 24 hours
- •Written informed consent signed by patients or their families
- •Exclusion criteria:
- •patients receiving thrombolysis or endovascular therapy;
- •modified Rankin scale (mRS) score ≥ 2 before this attack;
- •other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain;
- •Arterial blood pressure ≤ 90/60mmHg or ≥ 180/100mmHg after treatment.
排除标准
- 未提供
研究组 & 干预措施
standard therapy
Patients will be treated with Guideline standard
干预措施: standard therapy (Drug)
remote ischemic postcondioning and standard therapy
Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days.
干预措施: remote ischemic postcondioning (Procedure)
remote ischemic postcondioning and standard therapy
Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days.
干预措施: standard therapy (Drug)
结局指标
主要结局
Changes of glial lymphatic system
时间窗: from baseline to 3 day
The size of the vascular spaces was assessed by brain magnetic resonance of ischemic postcondioning group and standard therapy group
次要结局
- Differential expression pattern of differential proteins(from baseline to 3 day)