Effects of Anti-obesity Medications on 24h Energy Metabolism and Body Composition in Patients With Obesity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- change in 24h energy expenditure after 6 months of treatment
研究概览
简要总结
This study investigates the long-term effects of anti-obesity medications (Semaglutide and Tirzepatide) on energy metabolism (24-hour energy expenditure and substrate oxidation) and body composition via Dual-energy X-ray absorptiometry (DXA)
详细描述
This study will explore the long-term effects of obesity treatments, including anti-obesity medications (AOMs) such as GLP-1 receptor agonist (Semaglutide) and GIP/GLP-1 receptor agonist (Tirzepatide), on energy metabolism (24-hour energy expenditure and substrate oxidation), body composition (fat mass and fat-free mass). The study will include AOMs may lead to a state of metabolic adaptation, one of the reasons for weight regain. To date, no studies have assessed the effects of AOMs on 24-hour energy expenditure measured by using the metabolic chamber.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Body mass index (BMI) >= 30 kg/m² or >= 27 kg/m² with at least one weight-related comorbidity and stable body weight (±2 kg in prior 3 months)
- •informed consent, adherence to study protocol, negative pregnancy test and contraception use (if applicable), and absence of cardiovascular events or end-organ damage.
排除标准
- •psychiatric conditions impairing adherence, history of medullary thyroid cancer, pregnancy/lactation
研究组 & 干预措施
antiobesity medication and energy expenditure
patients with obesity for the administration anti-obesity medication (Semaglutide or Tirzepatide) for the clinical use.
干预措施: anti obesity medication (Drug)
结局指标
主要结局
change in 24h energy expenditure after 6 months of treatment
时间窗: Baseline and 6 months after treatment initiation
measurement of 24-hour energy expenditure (kilocalories) by using the metabolic chamber (whole room indirect calorimeter) at baseline and after 6 months of treatment
次要结局
- Change in body composition(Baseline and 6 months after treatment initiation)
研究者
Alessio Basolo
Researcher
University of Pisa