Inflammatory markers and other biochemical parameters in COVID -19 and their association with mortality outcome in Diabetes verses Non Diabetes patients of coastal karnataka tertiary care hospital.
- Conditions
- Acute upper respiratory infection,unspecified, (2) ICD-10 Condition: B972||Coronavirus as the cause of diseases classified elsewhere,
- Registration Number
- CTRI/2020/12/030070
- Lead Sponsor
- Dr Shaheen B shaikh
- Brief Summary
The pandemic coronavirus disease 2019 (COVID-19) has threaten the global health. The characteristics of inflammatory markers of coronavirus are of great significance for clinical diagnosis and treatment. Diabetes mellitus (DM) is challenging in the context of the COVID-19 pandemic. Diabetes is among the most frequently reported comorbidities in patients infected with COVID-19 .1 We found indicators that may most effectively predict a non-severe COVID-19 patient develop into a severe patient
Serum inflammatory markers are acute-phase-protein exhibiting elevated serum concentrations in various inflammatory diseases.2 Here we focus on the Comparing of serum markers for diagnostic and clinical management of patients with COVID-19 in comparison with diabetic and non diabetic patients.
**Objectives:**
**1.** **To** **evaluate and compare the** **Inflammatory markers in Diabetic and Non Diabetic patients with COVID – 19 in tertiary hospital of coastal Karnataka.**
**2.** **To Study the association of inflammatory markers to outcomes including duration of hospitalization, duration of ICU stay, duration of mechanical ventilation and mortality between** **Diabetic and Non Diabetic patients with COVID – 19 in tertiary hospital of coastal Karnataka.**
**Hypothesis:**
**COVID – 19 patients with Diabetic mellitus have raised Inflammatory markers and poor prognosis compared to non diabetes COVID – 19 patients .**
**Study design**: A Cross sectional study was conducted on COVID 19 positive adult patients (18 -70 years ) from April 1 st 2020 to December 31st 2020.
**Ethical clearance**: The study will be conducted after obtaining the approval from the institutional ethical committee.
**Inclusion criteria**: All the Covid 19 diagnosed (18 -70 years ) and admitted patients at yenepoya Medical college hospital. All patients were diagnosed based on the WHO recommendations for cases who have a positive RT - PCR test for SARS-CoV-2. The diabetic group included all patients with Diabetes on insulin and/or oral hypoglycemic agents . The non-diabetic group included all the other patients with no history of taking antidiabetic medication and who had normal random blood glucose and HbA1c on admission.
**Exclusion criteria**: Patients who had no laboratory investigations will be excluded pregnant females were excluded from the study
**Clinical data collection**: Data is collected after getting the approval from institutional ethical committee . Blood sugar and Hemoglobin A1c (HbA1c), Urea , Creatinine , Ferritin , LDH , CRP , ESR , Procalcitonin ,D Dimer , CBC ,LFT , Electrolyte concentrations and interleukin-6 (IL-6) on admission are taken , Length of stay ,Mehanical Ventilator and 30 days mortality were taken
Study period : 9 months (April 1 st 2020 to December 31st 2020).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 2000
- All the Covid 19 diagnosed (18 -70 years ) and admitted patients at yenepoya Medical college hospital. All patients were diagnosed based on the WHO recommendations for cases who have a positive RT.
- PCR test for SARS-CoV-2. The diabetic group included all patients with Diabetes on insulin and/or oral hypoglycemic agents . The non-diabetic group included all the other patients with no history of taking antidiabetic medication and who had normal random blood glucose and HbA1c on admission.
Patients who had no laboratory investigations will be excluded pregnant females were excluded from the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Evaluate and compare the Inflammatory markers in Diabetic and Non Diabetic patients with COVID – 19 in tertiary hospital of coastal Karnataka. 4 weeks
- Secondary Outcome Measures
Name Time Method compare the Inflammatory markers in Diabetic and Non Diabetic patients with COVID – 19 in tertiary hospital of coastal Karnataka. 4 weeks
Trial Locations
- Locations (1)
Yenepoya Medical College Hospital
🇮🇳Kannada, KARNATAKA, India
Yenepoya Medical College Hospital🇮🇳Kannada, KARNATAKA, IndiaDr Shaheen B shaikhPrincipal investigator9663165942drshaheenshaikh@yenepoya.edu.in