Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- IL-6
研究概览
简要总结
This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.
详细描述
IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI < 25 HbA1c < 7%
排除标准
- •Diabetic patients Known allergy to propofol
研究组 & 干预措施
Inhaled anesthesia (Sevoflurane)
Patients undergoing cardiovascular surgery with inhaled anesthesia with sevoflurane.
干预措施: Sevoflurane (Drug)
Total Intravenous Anesthesia (Propofol)
Patients undergoing cardiovascular surgery with total intravenous anesthesia with propofol.
干预措施: Propofol (Drug)
结局指标
主要结局
IL-6
时间窗: The difference between IL-6 at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass
IL-6 will be compared between the groups.
次要结局
- TNFα(The difference between TNFα at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass)
- Cortisol(The difference between cortisol at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass)