Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy
Phase 4
Completed
- Conditions
- Hyperalgesia
- Interventions
- Drug: remifentanil, MgSO4
- Registration Number
- NCT01025245
- Lead Sponsor
- Yonsei University
- Brief Summary
The purpose of this study is to study the effect of intraoperative magnesium on remifentanil-induced postoperative hyperalgesia after thyroidectomy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
- Patients undergoing thyroidectomy,
- Age 20-65,
- American Society of Anesthesiologists physical status classification I or II.
Exclusion Criteria
- History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs,
- History of drug & alcohol abuse,
- Psychiatric disorder,
- Use of opioids within 24hrs,
- Renal disease with decreased GFR,
- Neuromuscular disease, Severe cardiac disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description remifentanil, MgSO4 remifentanil, MgSO4 Experimental 1 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and MgSO4 30 mg/kg IV at the induction followed by intraoperative infusion at 10 mg/kg/hr Drug : remifentanil, MgSO4 Experimental 2 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and normal saline Drug : remifentanil Active comparator : Intraoperative remifentanil infusion at 0.05 ㎍/㎏/min and normal saline Drug : remifentanil
- Primary Outcome Measures
Name Time Method Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs postoperative 48 hrs
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Severance Hospital
🇰🇷Seoul, Korea, Republic of