NCT01025245已完成4 期
Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
研究概览
简要总结
The purpose of this study is to study the effect of intraoperative magnesium on remifentanil-induced postoperative hyperalgesia after thyroidectomy
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing thyroidectomy,
- •Age 20-65,
- •American Society of Anesthesiologists physical status classification I or II.
排除标准
- •History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs,
- •History of drug & alcohol abuse,
- •Psychiatric disorder,
- •Use of opioids within 24hrs,
- •Renal disease with decreased GFR,
- •Neuromuscular disease, Severe cardiac disease.
研究组 & 干预措施
remifentanil, MgSO4
Experimental
Experimental 1 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and MgSO4 30 mg/kg IV at the induction followed by intraoperative infusion at 10 mg/kg/hr Drug : remifentanil, MgSO4 Experimental 2 : Intraoperative remifentanil infusion at 0.2 ㎍/㎏/min and normal saline Drug : remifentanil Active comparator : Intraoperative remifentanil infusion at 0.05 ㎍/㎏/min and normal saline Drug : remifentanil
干预措施: remifentanil, MgSO4 (Drug)
结局指标
主要结局
Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
时间窗: postoperative 48 hrs
次要结局
未报告次要终点
研究者
研究点 (1)
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