Effect of Intraoperative Magnesium Infusion on Postoperative Pain and Cognitive Function After Pelvi-abdominal Surgeries :an Observational Study

This study will be conducted at Beni-Suef University Hospital after approval of the anesthesiology, surgical ICU and pain management department, and the local ethics and research committee, and obtaining written informed consents from the patients .

The inclusion criteria:

1. Male and female patients (age 20-60 years)
2. American Society of Anesthesiology(ASA) physical status I-II
3. Patients scheduled for elective pelvi-abdominal surgeries

The Exclusion criteria

1. Patients having significant cardiovascular (cardiomyopathy or moderate to severe valvular heart lesion) , significant hepatic disease (Child-Pugh score B or C ), renal or CNS disease
2. Patients with uncontrolled hypertension or diabetes
3. History of hypersensitivity to the drugs to be used
4. Control MMSE score ≤23
5. Women who are pregnant or breastfeeding
6. Patients taking Ca2+ channel blockers, opioids, antidepressants, or antipsychotics or alcohol
7. Patients having difficulty understanding , vision or hearing problems or CNS disorder as parkinson's disease .
8. Morbidly obese patients with a body mass index of >40
9. Patients who refused to be involved within the scope of the research. Management of the patients in the operation room All patients will be informed about the tests and written informed consent will be obtained from each of them. The MMSE will be applied. After arrival to the operation theater the monitors will be applied including will be applied including 5 leads ECG, non invasive arterial blood pressure and pulse oximetry. Urinary catheter will be inserted for urine output monitoring. Train of four (TOF) monitoring and Bispectral index (BIS) monitoring will be done in order to evaluate the depth of hypnosis (A-2000 Bispectral Index, Aspect Medical Systems, the Netherlands).