Cranberry Consumption Improves γδ T Cell Function

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Cranberry Beverage; Other: Placebo Beverage

• Registration Number: NCT01713829
• Lead Sponsor: University of Florida

Brief Summary

The purpose of this study is to determine the extent to which consuming a cranberry beverage modifies immune function, specifically related to γδ T cells and other innate immune cells. It is hypothesized that cranberry components will interact with immune cells to activate signaling pathways that enhance cell function. Enhanced immune cell function should result in reduced number, duration, and severity of cold and flu symptoms.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-09-18
• Study Start: 2012-10
• Study First Submitted QC: 2012-10-22
• Study First Posted: 2012-10-25
• Primary Completion: 2013-01
• Study Completion: 2013-08
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-10
• Last Update Posted: 2014-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• between 21 and 35 years of age and in good health
• have a BMI between 18.5 and 29.9
• willing to consume the study beverage for 12 weeks
• willing to have a small amount of blood drawn two times
• willing to stop consuming tea and immune-enhancing dietary supplements (e.g. antioxidant-, probiotic-, or flavonoid-containing supplements, fish oil, and Echinacea) before and during the 12 weeks of the study
• willing to consume no more than 7 servings of fruits and vegetables a day
• willing to limit your alcohol consumption to no more than 14 glasses a week
• willing to limit your yogurt consumption to no more than one 8oz. serving per day

Exclusion Criteria

• have food allergies
• have hypertension
• taking non-steroidal anti-inflammatory drugs on a chronic basis, antibiotics, or immunosuppressive drugs
• sensitive to aspirin or prone to kidney stones
• current smoker
• pregnant, lactating, or on hormone therapy, except for birth control pills

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cranberry Beverage	Cranberry Beverage	Cranberry Beverage is provided in an 8 oz daily beverage consumed once daily for 12 weeks
Placebo Beverage	Placebo Beverage	The placebo beverage looks like the active arm and is given in the same way but contains no active ingredient.

Primary Outcome Measures

Name	Time	Method
Change in Immune Cell Function	Measured at baseline and 6 weeks	* Change in leukocyte phenotype; * Change in the ability of the natural killer and/or γδ T cells to proliferate when cultured ex vivo; * Change in peripheral blood mononuclear cell cytokine and chemokine production in response to mitogens

Secondary Outcome Measures

Name	Time	Method
Cold and Flu Symptoms	12 weeks	Incidence and severity of cold and flu symptoms, total and individual. Other signs of severity, for example, visits to doctor or health clinic, reduction in daily activities, prescribed or over-the-counter medications taken.

Trial Locations

Locations (1)

449 Food Science and Human Nutrition Department, University of Florida; 🇺🇸 Gainesville, Florida, United States