Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Liver Transplantation

Completed

• Conditions: Liver Transplantation; Renal Function
• Interventions: Procedure: living donor liver transplantation

• Registration Number: NCT02080065
• Lead Sponsor: Samsung Medical Center

Brief Summary

The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but preoperative medication and intraoperative colloid administration and hemodynamic parameters have not been evaluated. Therefore, we attempt to evaluate perioperative risk factors and develop simplified clinical risk scoring model.

Detailed Description

Ischemia/reperfusion injury occurs during graft harvesting, cold storage, and surgical procedures in liver transplantation. Ischemia/reperfusion injury in liver graft results in major organ damage including kidney, lung and heart as well as graft dysfunction. Graft dysfunction and renal injury after liver transplantation are major clinical issues and are associated with prognosis and low survival rate. The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but perioperative medication, metabolic variables (albumin, glucose, uric acid), intraoperative colloid administration and hemodynamic parameters have not been evaluated. In addition, a neutrophil-lymphocyte ratio (NLR), which has been reported to be related to systemic inflammation and associated with prognosis of cardiac and cancer patients, might be related to the development of AKI after LDLT. Therefore, we attempt to evaluate these perioperative risk factors and develop simplified clinical risk scoring model.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-03-04
• Study First Submitted QC: 2014-03-05
• Study First Posted: 2014-03-06
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-27
• Last Update Posted: 2015-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 573

Inclusion Criteria

• Patients who underwent living donor liver transplantation between 2010 and 2013 in Samsung Medical Center

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Exclusion Criteria

• Incomplete data regarding pre- and postoperative creatinine and estimated Glomerular Filtration Rate
• patient who underwent retransplantation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
liver transplantation	living donor liver transplantation	patients who underwent living donor liver transplantation during between 2007 and 2013

Primary Outcome Measures

Name	Time	Method
acute kidney injury as defined by RIFLE criteria	during 7 days after transplantation	acute kidney injury as defined by RIFLE criteria

Secondary Outcome Measures

Name	Time	Method
incidence of retransplantation	during one month after transplantation	incidence of retransplantation
incidence of renal replacement therapy	during one month after transplantation	renal replacement therapy
incidence of acute rejection of graft	during one month after transplantation	incidence of acute rejection of graft
incidence of initial poor graft function	during one month after transplantation	incidence of initial poor graft function

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of