Interactions of the Vascular Barrier, the Cardiopulmonary, and the Body Fluids System during Hypobaric Hypoxic Winter Confinement in Antarctica.

• Conditions: T70.2; R60.9; Other and unspecified effects of high altitude; Oedema, unspecified

• Registration Number: DRKS00012678
• Lead Sponsor: Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-26
• Study Completion: 2021-04-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Individuals assigned to a winter-over mission at the Concordia station in Antarctica (hypobaric hypoxia)

- Individuals assigned to a winter-over mission at the Belgrano-II Antarctica station (normobaric normoxia)

- Written informed consent of the subject

Exclusion Criteria

- Candidate refuses to participate

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The difference of the averaged blood plasma concentration of nitric oxide between the group at altitude and the group at sea level is the primary outcome. Blood will be sampled on 13 time points during the winterover stay: after 2, 4 and 7 days and 2 and 4 weeks after arrival at the Station and after 2, 3, 4, 5, 6 ,8 ,10 and 12 months after arrival.

Secondary Outcome Measures

Name	Time	Method
The difference of the averaged blood serum concentration of hyaluronan between the group at altitude and the group at sea level is the secondary outcome. Blood will be sampled on 13 time points during the winterover stay: after 2, 4 and 7 days and 2 and 4 weeks after arrival at the Station and after 2, 3, 4, 5, 6 ,8 ,10 and 12 months after arrival.