The Pathophysiology of Disrupted Endothelial Barrier Integrity in Septic shock
Withdrawn
- Conditions
- blood poisoningSeptic shock10002252
- Registration Number
- NL-OMON49036
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- *18 years old
- Quick Sequential Organ Failure Assessment score (qSOFA score) *2 with
suspicion of infection
- MAP < 65 mmHg and lactate > 2 mmol/L despite volume resuscitation, requiring
vasopressors
- Inclusion within 12 hours after arriving on the Intensive Care Unit
Exclusion Criteria
- Absence of informed consent
- No arterial catheter placement * 12 hours after arriving on the Intensive
Care Unit
- Transfer from another hospital
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Transendothelial electrical resistance (TER)<br /><br>Electric Cell-substrate Impedance Sensing (ECIS) will be used to quantify<br /><br>endothelial barrier integrity.</p><br>
- Secondary Outcome Measures
Name Time Method