MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients
- Conditions
- HemophiliaVascular calcification Media sclerosisPeripheral arteriesArterial stiffness
- Registration Number
- NL-OMON23588
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
n.a.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Hemophilia A and B patients
2. Written informed consent for study participating
Exclusion Criteria
1. Patients with symptomatic atherosclerotic disease or history of arterial thrombotic events.
2. Patients with chronic kidney disease (CKD), defined as eGFR < 60 ml/ min, calculated according to the Modification of Diet in Renal Disease formula.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Peripheral artery MRI characteristics (wall thickness, media thickness and stiffness) in hemophilia patients with a normal ankle brachial index and in hemophilia patients with a high ankle brachial index.<br /><br>2. Carotid-(right) femoral pulse wave velocity and carotid-(left) radial pulse wave velocity in both groups. <br>
- Secondary Outcome Measures
Name Time Method 1. Relation between vessel wall characteristics, arterial stiffness and traditional cardiovascular risk factors. <br /><br>2.Relation between vessel wall characteristics, arterial stiffness and severity of haemophilia.<br>