MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients

Withdrawn

• Conditions: Bloedvat- aandoeningen: atherosclerose, vasculaire calcificaties, vaatstijfheid; Medial arterial calcification; mediasclerosis; 10064477

• Registration Number: NL-OMON41839
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

1. Hemophilia A and B patients
2. Males, 18 years and older, mentally competent
3. Documented ABI > 0.9 (previous measurements)
4. Written informed consent for study participation

Exclusion Criteria

1. Patients with symptomatic atherosclerotic disease or history of arterial thrombotic events.
2. Patients with chronic kidney disease , defined as eGFR < 60 ml/ min, calculated according to the Modi*cation of Diet in Renal Disease formula.
3. Patients with diabetes mellitus, defined as any history of diabetes or current diabetes (diagnosed by HbA1c >= 6.5% according to the American Diabetes Association diagnostic criteria)
4. Patients with any contraindication to MRI (pacemaker or claustrophobia)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Comparison of both arterial (medial) wall thickness and arterial stiffness<br /><br>between the two groups with 3T MRI<br /><br>2. Comparison of the arterial stiffness between the two groups with pulse wave<br /><br>velocity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Relation between vessel wall characteristics, arterial stiffness and<br /><br>traditional cardiovascular risk factors.<br /><br>- Relation between vessel wall characteristics, arterial stiffness and severity<br /><br>of haemophilia.</p><br>