Probiotics to reduce infection in patients admitted to the Intensive Care Unit

Phase 2

Completed

• Conditions: hospital acquired infection; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12617000783325
• Lead Sponsor: Fiona Stanley Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-29
• Last Update Posted: 7 December 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

* Admitted to the ICU or high dependency area for less than 48 hours
* Anticipated to require intensive care or high dependency area care beyond the next calendar day

Exclusion Criteria

1. less than 18 years of age
2. Absolute contraindication to receiving medication via the enteral route
3. Known to be receiving probiotic therapy at time of index hospitalisation
4. Acute pancreatitis as a cause or complication of current admission
5. Immunosuppressed, e.g. chemotherapy within four weeks of admission, receiving greater than or equal to 1.5mg/kg methylprednisolone daily or equivalent for more than four days
6. Neutropenia (neutrophil count less than 1x109/L)
7. Prosthetic heart valve or permanent pace maker
8. Death is deemed to be inevitable as a result of the current acute illness AND either the treating clinician, the patient, or the substitute decision maker are not committed to full active treatment
9. Enrolment not considered in the patient’s best interest
10. Previously enrolled in the ROCIT study
11. Unlikely to be residing in the Perth Metropolitan area in 60 days time
12. Participating in a competing interventional study
13. Pregnancy
14. Admitted to hospital from a high level nursing facility or rehabilitation facility

Study & Design

• Study Type: Interventional
• Study Design: Not specified