Personalizing Window of Implantation During Frozen Embryo Transfer
Not Applicable
Completed
- Conditions
- Fertility
- Registration Number
- NCT04840121
- Lead Sponsor
- Clinique Ovo
- Brief Summary
Embryo implantation is a crucial event in the establishment of a pregnancy. Although the clinical and culture conditions to obtain a "good quality" embryo are well advanced today, endometrial receptivity remains a major barrier in assisted reproductive techniques. Once a high-quality embryo is transferred, impaired uterine receptivity is believed to be one of the major reasons behind failure of the establishment of pregnancy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
- Women between the ages of 18 to 40 inclusive at the time of oocyte retrieval
- Prescription of a single frozen embryo transfer - substituted cycle protocol
- Participant has at least 2 vitrified good quality blastocysts
Exclusion Criteria
- Women undergoing fertility preservation
- Stage IV severe endometriosis
- Severe malformation, adenomyosis or uterine anomaly including fibroids deforming the uterine cavity ≥ 5 cm
- Positive results of screening for either participant or partner for HIV antibodies, Hepatitis B (other than surface antibodies present after vaccination) or Hepatitis C
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Determination of appropriate window of implantation 14 days after embryo transfer Comparison between standard frozen embryo transfer and personalized frozen embryo transfer using AdhesioRT to determine a successful window of implantation
- Secondary Outcome Measures
Name Time Method Rate of clinical pregnancy 14 days after embryo transfer Blood test to determine if the embryo transfer was successful or not
Trial Locations
- Locations (1)
Clinique Ovo
🇨🇦Montreal, Quebec, Canada
Clinique Ovo🇨🇦Montreal, Quebec, Canada