Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer

Not Applicable

Completed

• Conditions: Colorectal Cancer; Colon Rectal Resection; Oxidative Stress
• Interventions: Procedure: Surgery for colorectal cancer

• Registration Number: NCT01470586
• Lead Sponsor: G. Hatzikosta General Hospital

Brief Summary

Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

Detailed Description

Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

Study Timeline

• Study Start: 2009-05
• Primary Completion: 2010-10
• Study Completion: 2011-06
• Status Verified: 2011-11
• Study First Submitted: 2011-11-05
• Study First Submitted QC: 2011-11-10
• Last Update Submitted: 2011-11-10
• Study First Posted: 2011-11-11
• Last Update Posted: 2011-11-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with colorectal cancer
• Controls

Exclusion Criteria

• ASA>3
• Metastatic Disease
• Acute bowel obstruction
• Acute bowel perforation
• BMI<30
• Chronic Systemic or Autoimmune Diseases
• Smokers
• Alcohol consumers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Surgery for colorectal cancer	Surgery for colorectal cancer	Colorectal cancer patients

Primary Outcome Measures

Name	Time	Method
Comparison of Oxidative stress markers in patients with colorectal cancer and controls	up to 2 years	Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls

Secondary Outcome Measures

Name	Time	Method
Validation of oxidative stress markers in patients with colorectal cancer undergo surgical resection	up to 2 years	Validation of the responsiveness of markers of oxidative stress 8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG)on surgery

Trial Locations

Locations (1)

G. Hatzikosta General Hospital; 🇬🇷 Ioannina, Epirus, Greece