The Effect of Allopurinol on Percutaneous Coronary Intervention Outcomes in ST-segment Elevation Myocardial Infarction Patients

Phase 3

Recruiting

Conditions: Precancerous Coronary Intervention Outcome.
ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Registration Number: IRCT20181228042155N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Acute ST-segment elevation MI
Symptom onset below 24 hours
PCI as primary or rescue approach

Exclusion Criteria

Acute STEMI onset more than 24 hours
Candide for routine PCI
Previous consumption pf Allopurinol and other anti-inflammatory medications
Cardiac shock
Pulmonary edema with NYHA class 3/4
Mechanical complications of acute STEMI
Electrical complication of acute STEMI

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary flow according to Thrombolysis In Myocardial Infarction (TIMI flow). Timepoint: After precancerous coronary intervention. Method of measurement: Angioplasty videos interpretation.;Coronary flow according to Myocardial blush grade (MBG). Timepoint: After precancerous coronary intervention. Method of measurement: Angioplasty videos interpretation.

Secondary Outcome Measures

Name	Time	Method
Post MI Electrical and Mechanical complication. Timepoint: During hospitalization. Method of measurement: Electrocardiography and Echocardiography.;Major Adverse Cardiac Events (MACE). Timepoint: During hospitalization. Method of measurement: Questionnaire and physician interpretation.;Troponin level. Timepoint: Admission time and 48 hour after it. Method of measurement: Laboratory kit.;ECG changes. Timepoint: Admission time and after precancerous coronary intervention. Method of measurement: Objective interpretation.