Dose inidividualization of antimicrobials based on population pharmacokinetic analysis in patients undergoing blood purification therapy
Not Applicable
- Conditions
- sepsis
- Registration Number
- JPRN-UMIN000024321
- Lead Sponsor
- Kumamoto University Hospital
- Brief Summary
In vancomycin-administered-patients with continuous blood purification therapy, we identified reduced urine output (RUO, <0.5 ml/kg/h) and effluent flow rate were the factor for the vancomycin clearance. Using the pharmacokinetic model, The compliance rate for therapeutic trough concentration by the Bayesian estimation was higher (87.0%) than that by a conventional method (53.8%, P = 0.046). The variance was lower (11.5) by the Bayesian estimation than by a conventional method (50.5, P = 0.003).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
In state with impossible sampling of blood for measurement of blood antimicrobial concentration
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method