Effect of symbiotic on Allergic Rhinitis
Phase 3
- Conditions
- Perennial allergic rhinitis.Other allergic rhinitis
- Registration Number
- IRCT2017061223235N11
- Lead Sponsor
- Vice chancellor for research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
patients with persistent allergic rhinitis; Mashhad residents and surrounding towns; Have a positive skin test with Aeroallergen; Cooperate in projects Exclusion criteria: A history of autoimmune disease; Systemic corticosteroids or immunosuppressive drugs consumption and effective on immune system; Pregnant Women; Patients with immunodeficiency; Patients with malnutrition; Use Antibiotic during synbiotic consumption
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gene expression of FoxP3,TGF-ß,IL-17,IL-10,IL-4,IFN-?. Timepoint: Before intervention, after 2 month, after 6 month. Method of measurement: Real Time-PCR.;Quality of life. Timepoint: Before intervention, after 2 month, after 6 month. Method of measurement: questionnaire.
- Secondary Outcome Measures
Name Time Method Systemic reactions to immunotherapy. Timepoint: At every turn immunotherapy. Method of measurement: Clinical.